A new study published at the Journal of Urology shows a significant improvement in sexual and urinary functions and in the quality of life of men with hypogonadism who undergo long-term testosterone replacement therapy.
Testosterone is a steroid hormone involved in the regulation of sexual function, urinary tract health and metabolism, as well as other important functions. In most men, testosterone levels decrease slowly with age and cannot cause immediate serious symptoms. However, some people may experience many signs and symptoms, such as a clinical condition called testosterone deficiency (TD) or male hypogonadism, which is attributed to inadequate testosterone levels. As a result, they experience symptoms ranging from fatigue, erectile dysfunction, low energy, decreased mood, and increased risk of diabetes.
Scientists from the Boston University School of Medicine have worked with a group of urologists in Germany to investigate the effects of prolonged testosterone replacement therapy on urinary tract health, sexual function, and quality of life of men with diagnosed symptomatic testosterone deficits. The study included more than 650 men aged between 50 and 60, some with an unexplained testosterone deficiency and others with known genetic and autoimmune causes of hypogonadism.
Testosterone treatment in men would enlarge the prostate and aggravate symptoms of the lower urinary tract according to Dr. Abdulmaged Traish a professor of urology at BUSM.
However, he and Dr. Gheorghe Doros, professor of biostatistics at BUSPH, discovered that despite the increased size of the prostate in the testosterone therapy group, there were fewer urinary symptoms such as frequent urination, incomplete emptying of the bladder, weak urine flow and waking up at night.
In addition to these subjective improvements, scientists conducted objective tests that showed that men who were treated with testosterone emptied their bladders more completely. Finally, testosterone treatment also increased patient outcomes based on the evaluation of their sexual erection health and overall quality of life.
The results of this study are of great importance for men with symptomatic testosterone deficits. Traish emphasized the value of this treatment option and stated that testosterone therapy is well tolerated with progressive and continuous improvement of urinary and sexual function and overall quality of life.