Study Shows Omega-3 Fatty Acids May Offer New Hope in Treating Pulmonary Fibrosis and COPD

Overview of the Study

In a new study, a new benefit of omega-3 has just been documented by a team of University of Virginia intensive care physicians, who revealed that these fatty acids can slow fatal pulmonary fibrosis. The research, published in Chest Journal, reveals that these healthy fats, found in nuts and fish, can slow the progression of lung scar tissue, known as fibrosis, and delay the need for lung transplants.

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Omega-3 fatty acids

Omega-3 Fatty Acids

Key Findings and Implications

Lead author Dr. John Kim, a specialist in lung disease and critical care at UVA Health and the University of Virginia, and his team examined the relationship between plasma levels of omega-3 fatty acids and the progression of pulmonary fibrosis, as well as the length of time patients can go through without a lung transplant. The analysis showed that higher omega-3 levels were associated with better lung function and longer survival without transplantation.

“We found that higher levels of omega-3 fatty acids in the blood, representative of dietary intake over several weeks, were associated with better lung function and longer survival. These results suggest that omega-3 fatty acids may be a risk-reducing factor in pulmonary fibrosis.”

Broader Health Benefits of Omega-3 Fatty Acids

Omega-3 fatty acids have already been linked to numerous health benefits, including reducing the risk of heart disease, blood clots, stroke, breast, and other cancers, Alzheimer’s disease, and dementia.

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The study shows that they may also play a beneficial role in the progression of chronic lung diseases that can lead to pulmonary fibrosis.

Understanding Pulmonary Fibrosis

Although pulmonary fibrosis is becoming more common worldwide, it is an irreversible disease that causes the lungs to stop functioning properly, causing shortness of breath, weakness, the inability to exercise, and a host of other symptoms. Smoking is one of the main risk factors.

Research Methodology and Future Directions

The researchers examined anonymous data from patients referred to the Pulmonary Fibrosis Foundation registry and from patients followed at UVA Health and the University of Chicago, i.e., more than 300 patients with interstitial lung disease. Most patients were men and suffered from “idiopathic” pulmonary fibrosis, one of the conditions classified as interstitial lung disease. The analysis showed that:

  • Higher levels of omega-3 fatty acids in blood plasma are associated with better carbon dioxide exchange capacity and longer survival without transplantation.
  • The association persists regardless of smoking history or possible history of cardiovascular disease.
  • Higher levels of omega-3 fatty acids predict better clinical outcomes in pulmonary fibrosis.

Although more research is needed to understand exactly how omega-3s may exert this protective effect and to determine whether omega-3 fatty acid-based drugs or dietary changes can improve outcomes in patients with lung disease, these preliminary data call for clinical trials to determine whether interventions that increase omega-3 levels may be a useful tool to slow the progression of pulmonary fibrosis or even other chronic lung diseases.

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Final Thoughts

This study indicates that omega-3 fatty acids could be a valuable addition to treatments for pulmonary fibrosis and potentially other chronic lung conditions like COPD and asthma. The findings highlight the significant role of dietary elements in managing these diseases, setting the stage for further research into simple, diet-based interventions.


Kim, J. S., Ma, S.-F., Ma, J. Z., Ghosh, S., Maddipati, K., & Noth, I. (2023). Associations of plasma omega-3 fatty acids with progression and survival in pulmonary fibrosis. Chest Journal.



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