Category: Drugs
Rezpegaldesleukin Improved Moderate-to-Severe Eczema in a Phase 2b Trial, but the Bigger Test Is Still Ahead
An experimental biologic produced substantial improvements in adults with moderate-to-severe atopic dermatitis in a randomized phase 2b trial published in The Lancet. The drug, rezpegaldesleukin, works differently from many newer eczema …Ketamine May Change Negative Beliefs Within Hours in Treatment-Resistant Depression, Study Finds
Key Takeaways A JAMA Psychiatry study found that people with treatment-resistant depression showed changes in how they updated negative beliefs as early as four hours after their first ketamine …Is the Use of Psilocybin for the Treatment of Mental Health Disorders Haram (Forbidden) or Halal (Permissible) in Islam?
Key Findings: Recent studies show that psilocybin may be effective in treating depression, anxiety, trauma, eating disorders, and addiction, often outperforming other treatments. Psilocybin’s mind-altering effects conflict with Quranic …
The Scientific Value of External Control Arms in Clinical Research
Key Takeaways: External control arms use real-world or historical data to replace placebo groups in trials. They speed up research and reduce ethical concerns, especially in rare diseases. Regulators …
Personalized Melanoma Vaccines: What the Phase 3 Intismeran Results Actually Show and What Remains Unknown
A personalized mRNA cancer vaccine has succeeded in a Phase 3 melanoma trial, but that does not mean researchers have developed a vaccine that prevents melanoma—or that all of …
Upadacitinib Restored Substantial Scalp Hair in Severe Alopecia Areata, but Long-Term Safety and Durability Remain Unclear
Two Phase 3 trials involving 1,399 adults and adolescents found substantial scalp, eyebrow, and eyelash regrowth with upadacitinib after 24 weeks. The results are promising, but long-term safety, durability, …Macolacin a New Antibiotic That Can Kill Colistin-Resistant Bacteria a Welcome New Weapon for the Fight against Multidrug-Resistant Superbugs
As microorganisms mutate and procreate, each mutation makes them more resistant to drugs that once killed them. A time will eventually come when we cannot keep up with the …
HCG During Testosterone Replacement Therapy (TRT): Benefits, Fertility, Risks, and What the Evidence Shows
Key Takeaways Testosterone replacement therapy (TRT) and human chorionic gonadotropin (HCG) serve different purposes. TRT replaces testosterone, while HCG mimics luteinizing hormone (LH) to stimulate the testes. TRT can …