Scientists Discover Novel Feature in Bacteria That Could Help with the Manufacture of New Antibiotics

Bacteria have been a great source of active ingredients for the manufacture of many drugs, particularly antibiotics. Every living organism – animals, plants, fungi, and bacteria – is made up of vast chemical compounds that enable their interaction with, and survival in their environment; but that present in bacteria, among others, has been found to contain active ingredients that are useful in medicine, and this has paved the way for the manufacture of many drugs – antibiotics especially – from these organisms.

E. Coli Bacterial Resistance

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However, unraveling the mysteries behind the benefits of these microorganisms is quite difficult. One reason is that it is not easy to culture many types of bacteria in the laboratory. However, the use of bioinformatics and modern DNA sequencing methods has made the discovery of new active ingredients from these organisms easier. By employing this approach, the research team at ETH Zurich, led by Jorn Piel, has been able to discover new ways to synthesize peptides (small molecules of proteins) natural products that are relatively abundant in bacteria.

The research

The researchers analyzed the genome of several bacteria. They looked for genes that code for peptides, alongside those that code for the enzymes that act on these peptides (the action of these enzymes on the peptides is what gives rise to complex natural products in the bacteria). They were able to find these genes easily using search algorithms since each one displayed a distinct pattern.

The analyses showed that the enzymes were the determiners of the type of natural products to be produced by the bacteria. So, they separated the bacteria into several groups, based on the kind of enzyme present. They were unable to identify the function of the enzymes in one of the largest groups. Therefore, to confirm the computer predictions for three of the potential ingredients from this group, they conducted lab tests where they put the relevant genes into their already cultured laboratory bacteria, to investigate the substances they produce: a ring-shaped peptide molecule with a fatty acid appendage (a lipopeptide).

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The process involved in the manufacture of some already-produced antibiotics made from lipopeptides, like daptomycin, is a complex one. This is because the bacterium that produces the antibiotic also creates several kinds of natural products, of which only one is purified via an extremely difficult process before it can be used as a drug. However, this study has uncovered an easier way to generate a new class of lipopeptides to aid the easier manufacturing process of more antibiotics like daptomycin.

The researchers were able to improve on the coding sequence of the genes that control the enzymes via mutation, enabling them to create improved active ingredients. To be sure that this newly discovered active ingredient is safe to be used as a drug for human intake, researchers are currently looking into its biological function.

Clinical significance

The findings from this study have uncovered the discovery of new easier ways to manufacture more drugs from lipopeptides, to aid better control of bacterial infections in people suffering from them.

In addition, this study has unlocked the active ingredients for the production of novel antibiotics, making it easier for pharmaceutical companies to keep up in the race against antimicrobial resistance.

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Conclusion

Bacteria, among other organisms, are of utmost importance in the manufacture of antibiotics, which are useful in treating bacterial infections in humans. And findings from this study have opened the door to easier production of new drugs from these microorganisms.

FAQ: Bacteria and Antibiotic Production

1. Why are bacteria important in drug manufacturing?

Bacteria contain active ingredients that can be used to create many drugs, especially antibiotics, making them a valuable resource in medicine.

2. Why is it difficult to discover new antibiotics from bacteria?

Many bacteria cannot be easily cultured in a lab, making it challenging to study them. However, modern DNA sequencing and bioinformatics have helped identify useful bacterial compounds.

3. What did the ETH Zurich research team discover?

They found a new way to synthesize lipopeptides—small protein molecules that could lead to easier antibiotic production.

4. How did the researchers identify new antibiotic components?

They analyzed bacterial genomes to find genes coding for peptides and enzymes responsible for natural product formation.

5. Why is enzyme function important in antibiotic production?

Enzymes determine the type of natural products a bacterium can produce. Identifying these enzymes helps scientists categorize bacteria and predict their potential for new drug development.

6. What is a lipopeptide, and why is it significant?

Lipopeptides are ring-shaped peptide molecules with fatty acid attachments. They are used in antibiotics like daptomycin, but their production is complex. This study suggests an easier way to manufacture them.

7. How does this research make antibiotic production easier?

By modifying bacterial genes, scientists can improve active ingredient production, making it more efficient and scalable for drug development.

8. Are these newly discovered ingredients safe for humans?

The researchers are currently studying the biological function of these ingredients to determine their safety and effectiveness for human use.

9. What is the clinical significance of this study?

The findings could lead to the development of new antibiotics, helping combat bacterial infections and address antimicrobial resistance.

10. How does this research help fight antimicrobial resistance?

By discovering new ways to produce antibiotics, pharmaceutical companies can stay ahead in the battle against drug-resistant bacteria.

11. What impact does this have on pharmaceutical companies?

It provides an easier and more efficient way to develop new antibiotics, reducing manufacturing complexity and improving supply.

12. What is the main takeaway from this study?

Bacteria continue to be a key source of antibiotics, and this research paves the way for simpler, more effective drug production to combat bacterial infections.

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