The health consequences of obesity are numerous: diabetes, high blood pressure, cancer risk, etc. But there is also a tendency of obese people to be depressed. A surprising phenomenon, the mechanism of which the University of Glasgow researchers have finally explained.
Obese Man
“When we feel depressed, we tend to eat. The consumption of fatty foods gives us comfort. But in the long run, it can have the opposite effect,” says George Baillie, a researcher at the University of Glasgow, Scotland. He and his team have just discovered the process that links obesity and depression.
Read Also: John Hopkins Researchers Have Linked Late Eating to the Development of Diabetes and Obesity
Researchers at the University of Glasgow have been working on a mice model and discovered that saturated fatty acids tend to enter the brain via the bloodstream. They then accumulate in areas that control mood. In fact, mice that fed on a high-fat diet showed a high influx of dietary fatty acids into the hypothalamus region.
In the course of the new treatments
The researchers also observed an increase in the concentration of the free fatty acid receptor 1 (FFAR1) and a disruption in the signaling pathway of cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA), a protein suspected of playing an important role in the development of depression. On the other hand, a deficiency of an enzyme called phosphodiesterase 4A (PDE4A) – an enzyme involved in the breakdown of cAMP – has played a protective role in mice.
Read Also: Obese Adolescents at Higher Risk for Developing Cancer in Adulthood
Clearly, a high-fat diet may very well interfere with the function of the hypothalamus by activating the enzyme PDE4A and thus suppressing the cAMP/PKA signaling pathway. This discovery offers hope for the development of new therapies. It has been shown that conventional antidepressants take longer to work in overweight people. In addition to being less effective in obese people, it also takes antidepressants longer to work in them.
References
DIETARY FATS ENTERING THE BRAIN MAY EXPLAIN LINK BETWEEN OBESITY AND DEPRESSION
Related Articles:
British Scientists Report Link Between Obesity and Dementia
Losing Weight With HGH Supplements Is Now A Viable Option
Study Shows Avocados May Help You Fight Obesity and Diabetes
Obese Men with Hypogonadism Could Lose Weight and Keep It off with Testosterone Injections
Study Suggests Western Lifestyle Is Reducing Healthy Gut Bacteria
Ketogenic Diet: Health Benefits And Possible Side Effects
HGH Deficiency Symptoms And Latest Testing Options
Other Links you May like:
https://www.gilmorehealth.com/growth-factor-plus/
FEEDBACK:
