The Role of Lidocaine in Minimizing Discomfort during Hyaluronic Acid Dermal Filler Procedures

These days, hyaluronic acid (HA), one of the main components of dermal fillers is used to help rejuvenate and enhance the overall appearance of a patient in a natural-looking way. However, can HA be mixed with lidocaine?



What Is Hyaluronic Acid?

When defining hyaluronic acid, it is essential to differentiate between naturally occurring and the synthetic type used in cosmetic products:

  • Hyaluronic acid is a naturally occurring substance in the human body that is primarily found in the joints, eyes, and skin. HA has the power to attract and retain moisture within the cells. Therefore, it serves as an efficient hydrator of tissues.
  • Synthetic HA however serves as a substitution for the naturally-occurring one. Therefore, it often serves as one of the main ingredients for a wide range of cosmetic products, such as serums, masks, and dermal fillers.

It is important to mention that the natural production of HA in the human body tends to slow down with aging which eventually leads to quick skin aging.

Read Also: What Doctors Don’t Tell You about the Long-Term Effects of Using Facial Dermal Fillers

Luckily, the usage of synthetic HA that is found in cosmetic products might substantially slow down the skin aging process by means of:

  • Moisturizing skin tissues
  • Accelerating the natural production of collagen
  • Nurturing body cells

A safety note: Please note that an injection of any HA-based filler (for instance, Juvederm Ultra) is not compatible with simultaneous laser treatments or chemical peels. 

Therefore, HA dermal fillers are among the most effective cosmetic solutions to rejuvenate and enhance the skin and  they are injected into the mid to deep dermis to:

  • Reduce the appearance of mild, middle, or severe wrinkles (for instance, nasolabial folds, marionette lines, and crow’s feet)
  • Participate in restoring the lost volume of the face
  • Create a profound lip augmentation.

HA filler treatment is capable of providing a patient with safe, effective, and durable rejuvenation and enhancement. On average, the result of the procedure lasts up to two years. As soon as it wears off, a patient might ask a medical professional to repeat treatment.

Quality is important

Beauty Dermal, a supplier of dermal fillers, advises avoiding counterfeit products and ensuring the use of only genuine, high-quality dermal fillers such as Belotero, Restylane, and Juvederm. It is crucial to purchase these products from reputable sources to guarantee the best care for patients.

A safety note: Please keep in mind that a dermal filler is a product intended for professional use. Thus, it is an injectable gel that should be administered beneath a patient’s skin exclusively by a certified medical professional.

What Is Lidocaine?

Lidocaine hydrochloride, in its turn, is a popular local anesthetic. It is oftentimes used to ensure less patient discomfort while undergoing a wide range of medical and cosmetic procedures.

Many forms of lidocaine exist. Namely, it might:

  • Come in the form of a topical gel, cream, or spray;
  • Be preadded to the composition of medical and cosmetic products.

There is no significant difference in the effectiveness of a topical gel, cream, or spray with lidocaine. At the same time, injectable lidocaine tends to provide a patient with the best possible efficacy and safety profile.

Read Also: Neck Lift Procedures: Trampoline Platysmaplasty a Safer Alternative to Corset Platysmaplasty for Neck Rejuvenation

Under normal circumstances, lidocaine substantially reduces the average pain rating in a particular area of the body for a time period from half an hour to several hours.

A safety note: Please note that, apart from minimizing pain, lidocaine might, at the same time, cause a number of side effects and allergic reactions. Thus, a medical professional should make sure that the anesthetic is safe in each individual case before applying it.

Is It Possible to Mix Hyaluronic Acid and Lidocaine?

A very short answer to the question of whether it is possible to mix hyaluronic acid and lidocaine will be: “Yes, it is possible.” So, how about delving into the topic in detail:

  • Firstly, it is important to mention that a great number of HA-based dermal fillers contain lidocaine. Together, these two components constitute a perfect formula to rejuvenate a patient’s face in a pain-free manner. Therefore, such cosmetic injectables as Belotero, Restylane, or Juvederm fillers contain HA mixed with adjunctive lidocaine.
  • Secondly, adjunct lidocaine (compared to the absence of it) in the composition of HA dermal fillers has proven to cause significantly less pain. Based on numerous patient questionnaires, more than 70% of people who have been treated with HA-based cosmetic injectables with lidocaine claimed the procedure to be virtually painless (no matter whether it has been performed to augment facial volume, reduce facial wrinkles, or plump lips);
  • Thirdly, it is worth saying that HA is fully compatible with lidocaine. Such a combination rarely leads to an allergic reaction, an adverse reaction, or a side effect of severe intensity. Still, keep in mind that some people might experience rare complications after the injection of any HA gel premixed with lidocaine.

Therefore, the clinical outcome of lidocaine’s presence in the composition of a dermal filler usually leads to substantially increased patient satisfaction after the procedure.

Read Also: Enhancing Natural Beauty: Plastic Surgery and the Concept of Aesthetics


American Society of Plastic Surgeons. (2023). Dermal Fillers. Retrieved June 29, 2023, from

American Board of Cosmetic Surgery. (n.d.). Injectable Dermal Fillers Guide. Retrieved June 29, 2023, from



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