Scientists Reveal Strategies to Block Hypertrophic Scars

Strategies for Prevention of Hypertrophic Scars

Current treatments for this skin condition are mostly invasive. It depends mainly on simple surgical excision.

Researchers set out to find ways to prevent HS from forming at all in the recent paper. They were interested mainly in treatments that were not surgical.

The team found that pressure therapy, a popular non-invasive treatment for skin scarring, could help greatly. However, the proven remedy appeared to help most when performed within two months of suffering an injury.

According to the paper, topical steroids can be beneficial to patients with burn injuries. The compounds help to inhibit chronic inflammation that could lead to skin scarring.

The use of ablative fractional lasers in dealing with scars is becoming more popular. Evidence showed that laser treatment can prevent HS formation when done early. However, the scientists noted that further research is vital to better understand how this treatment prevents HS from forming.

The popular aesthetic drug Botox, specifically botulinum toxin A (btxA), was also promising. But the researchers who prepared this paper suggested a need to first determine the ideal drug strength to use.

The paper nonetheless proposes resection and radiation as possibly useful secondary treatments in some cases. Surgical excision with postoperative radiation within the first two days of an injury helps to prevent larger scars, which are common with a regular procedure. Radiation therapy reduces inflammation and regulates the production of fibroblasts.

The scientists, however, indicated the need for long-term results to verify the reliability of resection or radiation as an adjunct for HS.

In addition, the paper also draws attention to some treatments that could help manage HS effectively in the future. These include anti-inflammatory therapy, anti-angiogenesis therapy, and adipose-derived cell therapy.

Read Also: Wrinkles: Evaluating Types and Treatment Options


Strategies to prevent hypertrophic scar formation: a review of therapeutic interventions based on molecular evidence. Shirakami et al. Burns & Trauma, 27 January 2020. (

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