Guillain-Barré Syndrome Observed after the First Dose of the Astrazeneca Vaccine

In addition to the cases of thrombosis, doctors are now seeing in some patients Guillain-Barré Syndrome a rare neurological disorder following the injection of AstraZeneca’s vaccine. The causal link between the vaccine and these symptoms is not clear.AstraZeneca COVID-19 Vaccine

In India, in the southwestern state of Kerala, doctors at Kochi City Hospital reported the development of Guillain-Barré syndrome in seven people, all of whom had received a first dose of AstraZeneca’s vaccine. Similar reports were made by Nottingham University Hospitals, NHS Trust England. A total of 11 subjects reported paresthesias, tingling and bifacial weakness. A causal link between these typical Guillain-Barré symptoms and AstraZeneca’s vaccine was not established.

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Rare cases of neurological disorders observed after Covid vaccination

Among the 11 individuals identified among the millions vaccinated, it is difficult to establish a typical profile. The Indian doctors treated six women and one man aged 43 to 68, while the English doctors treated only men aged 20 to 57.

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All had symptoms 10 to 20 days after the first dose of AstraZeneca’s vaccine. Patients were hospitalized for tingling and weakness in their limbs. facial palsy occurred on average 4 days after hospitalization. These people are not in life-threatening situation. Apart from these symptoms, their general health seemed to be good.

Guillain-Barré syndrome can result from an acute infectious disease. Some people have reported it as a result of Covid-19, without formal evidence of the link between the two pathologies. In this case, the patients did not have Covid-19 prior to their vaccination. Doctors at Nottingham Hospital speculate that these cases may be due to the cross-reaction of antibodies that recognize the myelin surrounding peripheral neurons. These antibodies may arise after exposure to protein S or the adenovirus in the vaccine.

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References

Guillain-Barré Syndromefollowing ChAdOx1-S/nCoV-19Vaccine

Guillain-Barré syndrome variant occurring after SARS-CoV-2 vaccination

 

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