Key Takeaways
- GenF20 Plus is a supplement designed to support natural HGH production using amino acids and herbal extracts.
- One small, manufacturer-funded study showed increased IGF-1 levels, but clinical benefits remain unproven.
- Most ingredients are underdosed compared to amounts used in research, limiting their potential effect.
- It may offer mild benefits for energy, sleep, or muscle tone in some adults over 40, but results vary.
What Is GenF20 Plus?
As we age, especially after 40, natural levels of human growth hormone (HGH) decline, contributing to fatigue, decreased muscle mass, wrinkles, and reduced libido. Marketed as an alternative to prescription hormone therapy, GenF20 Plus is a dietary supplement that may help stimulate the body’s natural HGH production through amino acids and herbal ingredients, without synthetic hormones or needles.
Genf20 Plus
Unlike injectable HGH therapy, which is costly, tightly regulated, and requires medical supervision, GenF20 Plus uses oral tablets and a spray containing amino acids and plant-based compounds to stimulate the pituitary gland’s HGH output. It’s available over the counter and does not require a prescription.
How Does GenF20 Plus Work?
HGH, or human growth hormone, is released by a gland in your brain called the pituitary. This release is triggered by a signaling molecule called growth hormone-releasing hormone (GHRH), which is produced by the hypothalamus. As we age, the function of both the hypothalamus and pituitary gland declines, leading to reduced GHRH output and lower HGH levels.
GenF20 Plus contains amino acids like L-Arginine, L-Glutamine, and L-Glycine, which may stimulate GHRH release or enhance pituitary activity. The product also includes an oral spray with Alpha-GPC, an ingredient shown in some research to support growth hormone release through enhanced neurotransmitter activity.
Broader Context: HGH and Aging
As we age, HGH levels naturally decline. This drop may lead to less muscle mass, lower energy, and more wrinkles. While HGH injections are effective, they require prescriptions and come with risks. GenF20 Plus aims to support the body’s own HGH production using natural ingredients like amino acids and herbs. The 1990 NEJM study by Rudman et al. focused on recombinant human growth hormone injections in older men and demonstrated improvements in lean body mass and bone density. It did not assess amino acid supplementation.
Scientific Insight:
A 2008 study published in the Journal of the International Society of Sports Nutrition found that Alpha-GPC supplementation was associated with a statistically significant increase in post-exercise HGH levels in a small sample of resistance-trained men. However, the study’s short duration and focus on acute exercise limit its generalizability to long-term HGH support.
What Does the Clinical Research Say?
GenF20 Plus references a 12-week, double-blind, placebo-controlled clinical study involving 61 participants aged 40+. Participants were randomized to receive either GenF20 Plus or a placebo. Results showed a statistically significant increase in insulin-like growth factor-1 (IGF-1) levels—a surrogate marker of HGH. However, the study did not report the clinical impact of this increase (e.g., changes in body composition or energy levels). Additionally, baseline IGF-1 variability and the size of the placebo response were not clearly outlined, limiting interpretation of efficacy.
⚠️ Note: Important: The cited study was sponsored by GenF20 Plus’s manufacturer, raising concerns about potential bias. Independent replication in peer-reviewed trials is necessary before drawing firm conclusions about effectiveness. We have conducted a GenF20 Plus clinical study deep dive, analyzing its strengths and weaknesses.
While the manufacturer-funded study provides promising results, independent research on HGH supplements is limited. A 2020 review in Current Developments in Nutrition (Apolzan, J. et al., 2020) found that amino acids like L-Arginine and L-Glutamine may modestly increase HGH in specific contexts, such as exercise, but effects vary widely. Larger, independent trials are needed to confirm GenF20 Plus’s efficacy and long-term safety.
Genf20 Plus Ingredients
Endorsement from Expert:
Dr. Steven Lamm, MD, Director of NYU’s Men’s Health Center, has reviewed GenF20 Plus and expressed support for its ingredient profile based on available research. However, this is a general endorsement and not a substitute for clinical guidance. Dr. Lamm has disclosed no financial ties to the product.
Benefits of GenF20 Plus (According to Users and Preliminary Research)
According to both the manufacturer-sponsored trial and anecdotal user reports, noticeable changes may occur after 2 to 3 months of use. These include:
- Increased energy and stamina in some individuals
- Modest improvements in muscle tone with exercise
- Reduced visceral fat in certain cases
- Improved skin elasticity
- Enhanced mood or mental clarity for some users
- Better sleep quality in select cases
💡 Caution: Benefits vary widely and are not guaranteed. Results depend on individual factors like diet, exercise, and health status. Claims like “look 10 years younger” lack robust evidence and should be approached with realistic expectations.
Ingredients in GenF20 Plus
The formula includes natural ingredients believed to support HGH production. Below is a summary of key ingredients, their purported effects, and the strength of supporting evidence:
| Ingredient | Purported Effect | Evidence Strength |
|---|---|---|
| L-Arginine | Boosts HGH during exercise | Moderate (studies show modest HGH increase) |
| L-Glutamine | Supports metabolism, immunity | Weak (limited direct HGH evidence) |
| L-Glycine | Stimulates pituitary | Moderate (some studies support HGH role) |
| Alpha-GPC | Enhances HGH release | Moderate (study supports post-exercise HGH) |
| Astragalus Root | Immune support | Weak (no direct HGH evidence) |
| GABA | Supports HGH, reduces stress | Weak (preliminary studies only) |
| Colostrum | Supports recovery | Weak (limited HGH-specific data) |
These ingredients are generally recognized as safe when used as directed. The supplement contains no synthetic hormones or harmful chemicals.
Scientific Perspective on GenF20 Plus Ingredients
While GenF20 Plus includes a blend of amino acids and nutrients commonly associated with HGH stimulation, it’s worth examining how these ingredients have performed in peer-reviewed research, and at what doses.
L-Arginine (520 mg per serving):
L-Arginine is one of the most studied amino acids for stimulating HGH release. Research suggests that doses around 5 to 9 grams (5,000 to 9,000 mg) may increase growth hormone levels, especially when taken without food (Kanaley, 2008). At 520 mg per serving, GenF20 Plus provides only a fraction of the amount used in those studies, so the effect may be limited.
L-Glutamine (460 mg):
L-Glutamine has been shown in some small studies to stimulate HGH production. One study using just 2 grams (2,000 mg) saw modest increases in HGH (Welbourne, 1995). Given the low dose of 460 mg, well below the 2,000 mg shown to have a minor effect, any HGH stimulation from L-Glutamine in this formulation is likely negligible for most users.
L-Glycine (460 mg):
Glycine may support HGH release and is often included in anti-aging supplements. A dose of 5.6 grams or more has been shown in a study to elevate HGH modestly, so GenF20 Plus’s 460 mg per serving is below that threshold (Kasai, Kobayashi, & Shimoda, 1978).
L-Tyrosine (400 mg):
L-Tyrosine is included in GenF20 Plus as part of its HGH-releasing formula. While tyrosine is involved in neurotransmitter production, evidence of it directly increasing HGH is limited. A 1972 study found that plasma tyrosine levels declined during early sleep when HGH typically peaks, but the same decline occurred even when HGH was absent, suggesting no direct cause-and-effect relationship (Zir et al., 1972). Based on current research, tyrosine’s contribution to HGH release appears indirect at best.
GABA (200 mg):
A 2008 study by Powers et al found that 3 grams of GABA—15 times the dose found in GenF20 Plus—led to short-term increases in HGH. GenF20 Plus provides only 200 mg per serving, making it unlikely to replicate this effect. Current research does not confirm whether lower doses yield any measurable benefit.
Colostrum (200 mg):
Bovine colostrum contains growth factors and immune-supporting compounds. A 2021 review noted its potential health benefits, but most studies use much higher doses than found in GenF20 Plus (Arslan et al., 2021). Its effect on HGH levels in adults remains unproven.
L-Ornithine (100 mg):
In a 2010 study, combining L-Ornithine with L-Arginine significantly increased HGH and IGF-1 levels after resistance training in strength-trained men, but the dose used was several grams (Zajac et al., 2010). GenF20 Plus contains just 100 mg, which is far below the level shown to have an effect.
Deer Antler Velvet (Spray component):
This ingredient is included for its IGF-1 content, which may be associated with HGH-like activity. However, the concentration and actual absorption of IGF-1 from oral sprays remains controversial, and the dose used in GenF20 Plus is not clearly quantified.
Delivery System: Tablets + Oral Spray
GenF20 Plus uses a dual delivery system:
- Enteric-coated tablets: Resist stomach acid, delivering ingredients to the small intestine for up to 90% absorption efficiency.
- Oral spray: Contains Alpha-GPC and herbal extracts to boost absorption and bioavailability.
This approach aims to enhance nutrient uptake and maximize results when used together.
Are There Any Side Effects?
Most users tolerate GenF20 Plus well. Mild side effects may include:
- Digestive discomfort (bloating, nausea)
- Headaches in sensitive individuals
- Sleep disturbances (rare)
People with chronic illnesses or on medication should consult a doctor before use. The FDA does not regulate dietary supplements like GenF20 Plus, so quality and efficacy may vary. Choose products with third-party testing for safety.
What Do Customers Say?
Thousands of customers have shared testimonials online praising the supplement’s impact on:
- Skin tone and elasticity
- Workout performance and recovery
- Mental clarity and libido
However, some users report minimal effects, citing high cost or slow results. Results are anecdotal and should not replace medical advice, emphasizing that GenF20 Plus is not a miracle pill.
Price, Discounts, and Where to Buy
GenF20 Plus is available exclusively through its official website. Pricing and offers are as follows:
| Supply Length | Regular Price | Discounted Price | Total Savings |
|---|---|---|---|
| 1 Month | $79.95 | $69.95 | $10 |
| 3 Months | $239.85 | $199.85 | $40 |
| 6 Months + Spray | $479.70 | $399.70 | $80 + Free Shipping |
💸 Best Deal: Six-month combo package at $58/bottle with free global shipping.
🛡️ Money-Back Guarantee: The manufacturer offers a 67-day return policy, allowing customers to try the product risk-free.
FAQs: GenF20 Plus and HGH Support
Who should consider GenF20 Plus?
Adults over 40 experiencing mild age-related symptoms like low energy, reduced muscle tone, or poor sleep may consider it after consulting a doctor.
Who should avoid GenF20 Plus?
Individuals with chronic conditions (e.g., diabetes, heart disease), those on medications, or pregnant/breastfeeding women should avoid it unless cleared by a healthcare provider.
How long until results appear?
Some users report benefits after 2–3 months of consistent use, but results vary based on lifestyle and health.
Is GenF20 Plus a substitute for HGH therapy?
No. It may modestly support natural HGH production but is not equivalent to medical HGH injections, which require prescription and supervision.
Can lifestyle enhance results?
Yes. A balanced diet, regular exercise, and adequate sleep may amplify the supplement’s effects, as HGH production is influenced by lifestyle.
Is GenF20 Plus Worth Trying?
If you’re over 40 and exploring ways to gently support hormone function without prescriptions or injections, this supplement might appeal to you. But it’s essential to temper expectations—it’s not a magic bullet, and the science behind it is still evolving. It may support natural hormone balance, which some users report helps with age-related symptoms like fatigue or reduced muscle tone, though results vary and are not guaranteed.
However, it’s not a substitute for medical HGH therapy, and results are more subtle and gradual. The FDA does not regulate dietary supplements, so choosing a product with third-party testing is advisable.
FAQs on Genf20 Plus
What is GenF20 Plus?
A supplement that may help boost your body’s natural HGH levels using amino acids and herbs.
Does it really work?
It may help some people, but results vary. One small study showed an increase in IGF-1, but more research is needed.
Is it safe?
Generally safe for healthy adults, but check with your doctor if you have any health conditions.
How long before I see results?
Some users notice changes in 2–3 months, but it’s not guaranteed.
Is this the same as HGH shots?
No. It’s not a substitute for prescription HGH therapy.
Where should I buy it?
Only buy from the official website to get the money-back guarantee.
Final Thoughts
GenF20 Plus stands out among HGH supplements for its transparent ingredient profile, dual-delivery system, and backing by a well-known manufacturer. It has earned thousands of positive customer reviews, with many users reporting improvements in energy, sleep, skin appearance, and exercise recovery. While these results remain anecdotal, they contribute to the product’s strong reputation in the wellness space.
That said, clinical support for GenF20 Plus remains limited. The one published study, though promising, was funded by the manufacturer, and most ingredients are present at doses lower than those used in peer-reviewed trials. Consumers should approach claims with measured expectations and understand that results will vary based on individual health and lifestyle.
The risk of serious side effects appears low, and the product is backed by a 67-day money-back guarantee, offering users a relatively safe opportunity to evaluate its effects firsthand. For those over 40 looking for non-prescription support for age-related changes, GenF20 Plus may be worth considering as part of a broader wellness strategy.
Importantly, lifestyle habits such as high-intensity interval training (HIIT) and a protein-rich diet have also been shown to naturally enhance HGH production and may further support results when combined with a supplement like GenF20 Plus.
As always, consult with a healthcare provider before beginning any supplement regimen.
Before You Buy – Key Takeaways
✔️ Backed by a small, manufacturer-funded clinical study
✔️ Contains well-researched natural ingredients
✔️ Dual-delivery system enhances absorption
✔️ 67-day money-back guarantee
❌ Lacks large-scale, independent trials
❌ Some claims are not fully substantiated
❌ Results vary widely among individuals
Where to Buy GenF20 Plus
To ensure product authenticity and qualify for discounts, purchase only from the official GenF20 Plus website.
References
Kanaley, J. A. (2008). Growth hormone, arginine and exercise. Current Opinion in Clinical Nutrition & Metabolic Care, 11(1), 50–54. https://doi.org/10.1097/MCO.0b013e3282f2b0ad
Goel, A., Lao, A., & Shirsath, K. (2015). Effect of GenF20 Plus on serum IGF-1 levels in healthy adults: A randomized controlled study. Open Access Journal of Clinical Trials, 7, 1–6. https://doi.org/10.2147/OAJCT.S75969
Ziegenfuss, T., Landis, J. & Hofheins, J. Acute supplementation with alpha-glycerylphosphorylcholine augments growth hormone response to, and peak force production during, resistance exercise. J Int Soc Sports Nutr 5 (Suppl 1), P15 (2008). https://doi.org/10.1186/1550-2783-5-S1-P15
Ishida, J., Saitoh, M., Ebner, N., Springer, J., Anker, S. D., & von Haehling, S. (2020). Growth hormone secretagogues: History, mechanism of action, and clinical development. Reviews in Endocrine and Metabolic Disorders, 20(1), Article e9. https://doi.org/10.1002/rco2.9
Rudman, D., Feller, A. G., Nagraj, H. S., Gergans, G. A., Lalitha, P. Y., Goldberg, A. F., Schlenker, R. A., Cohn, L., Rudman, I. W., & Mattson, D. E. (1990). Effects of human growth hormone in men over 60 years old. The New England Journal of Medicine, 323(1), 1–6. https://doi.org/10.1056/NEJM199007053230101
Apolzan, J., Rood, J., Beyl, R., Yang, S., Greenway, F., & Lieberman, H. (2020). Acute arginine supplementation is associated with increased growth hormone in younger healthy males: A randomized controlled trial. Current Developments in Nutrition, 4(Supplement_2), nzaa049_002. https://doi.org/10.1093/cdn/nzaa049_002
Welbourne, T. C. (1995). Increased plasma bicarbonate and growth hormone after an oral glutamine load. The American Journal of Clinical Nutrition, 61(5), 1058–1061. https://doi.org/10.1093/ajcn/61.4.1058
Kasai, K., Kobayashi, M., & Shimoda, S. I. (1978). Stimulatory effect of glycine on human growth hormone secretion. Metabolism, 27(2), 201–208. https://doi.org/10.1016/0026-0495(78)90165-8
LEONARD M. ZIR, DONAL C. PARKER, RICHARD A. SMITH, LAWRENCE G. ROSSMAN, The Relationship of Human Growth Hormone and Plasma Tyrosine During Sleep, The Journal of Clinical Endocrinology & Metabolism, Volume 34, Issue 1, 1 January 1972, Pages 1–6, https://doi.org/10.1210/jcem-34-1-1
Powers, M. E., Yarrow, J. F., McCoy, S. C., & Borst, S. E. (2008). Growth hormone isoform responses to GABA ingestion at rest and after exercise. Medicine & Science in Sports & Exercise, 40(1), 104–110. https://doi.org/10.1249/mss.0b013e318158b518
Arslan, A., et al. (2021). Bovine colostrum and its potential for human health and nutrition. Frontiers in Nutrition, 8, 651721. https://doi.org/10.3389/fnut.2021.651721
Zajac, A., Poprzecki, S., Zebrowska, A., Chalimoniuk, M., & Langfort, J. (2010). Arginine and ornithine supplementation increases growth hormone and insulin-like growth factor-1 serum levels after heavy-resistance exercise in strength-trained athletes. Journal of Strength and Conditioning Research, 24(4), 1082–1090. https://doi.org/10.1519/JSC.0b013e3181d321ff
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