Scientists from the University of Sheffield and Oxford recently discovered a new tech to repair DNA damage that was responsible for aging and other more serious conditions such as Motor Neuron Disease (MND) and cancer.
Research findings revealed a unique protein TEX264 that could identify toxic proteins attached to DNA. TEX264 along with other enzymes also phagocytosed these toxic proteins that were responsible for DNA damage. Chronic damage to DNA causes a buildup of abnormal DNA that has been strongly linked to cancer, aging, and severe neurological conditions.
DNA damage resulting from such toxic proteins has been thought to be irreversible so far. However, with the new discovery of TEX264, scientists believe the tech to repair the DNA damage may be as simple as a repair toolkit for the toxic proteins.
By purposeful breakage of DNA bound by toxic protein, a newer form of chemotherapy to destroy malignant tumor cells may soon be possible. Target destruction of TEX264 protein could be a novel treatment that could revolutionize cancer management.
Professor Sherif El-Khamisy, Co-Founder and Deputy Director of the Healthy Lifespan Institute at the University of Sheffield and a professor from the Department of Molecular Biology and Biotechnology and the Neuroscience Institute at the University of Sheffield, one of the lead researchers from the study said: “Failure to fix DNA breaks in our genome can impact our ability to enjoy a healthy life at an old age, as well as leave us vulnerable to neurological diseases like Motor Neurone Disease (MND). We hope that by understanding how our cells fix DNA breaks, we can help meet some of these challenges, as well as explore new ways of treating cancer in the future.”
TEX264, a protein that can engulf and destroy toxic proteins attached to DNA has changed the outlook and previous understanding of cell damage and repair process. The newly discovered protein may pave the way to reverse or slow down the aging process. The researchers are now focusing on the protein’s potential as a curative treatment for cancer. The research was funded by a number of prestigious funding bodies such as the Medical Research Council, Oxford Institute for Radiation Oncology, and the Department of Oncology.
120 renowned researchers from across the world are involved in the Healthy Lifespan Institute, whose primary focus has always been on slowing down the aging process as well as reducing the multiple comorbid conditions seen in aging populations with a goal to improve the quality of life in all aging individuals.
Researchers say the next phase of their research will be targeted at evaluating the protein TEX264’s effect on altering the aging process and Motor Neuron Disease.
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